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Transport of GM1 and GM1 Inner Ester Across an in Vitro Model of the Blood-Brain Barrier

Transport of GM1 and GM1 Inner Ester Across an in Vitro Model of the Blood-Brain Barrier

J M Wells, R F Ventura, P B Eisenhauer, D C McKenna, R E Fine, M D Ullman

Neurosci Lett. 1996 Oct 18;217(2-3):121-4.

PMID: 8916087

Abstract:

Gangliosides, especially GM1, attenuate the in vivo damage caused by various neurotoxins. The chemically neutral inner ester of GM1 may be a better cytoprotective agent against some neurotoxins than the parent GM1 compound, because it may cross the blood-brain barrier (BBB) more easily than the anionic GM1. Using an in vitro bovine brain endothelial cell model of the BBB, we show the inner ester more readily transverse the tight junction barrier of this model than does GM1. Further, it is demonstrated that the GM1 inner ester is stable for several hours at pH values between 7.0 and 8.2 at 37 degrees C. Finally, the results illustrate that the BBB model may be useful for testing other gangliosides and their various derivatives for increased ability to cross the BBB.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP71012196-A	Asialoganglioside GM1 from bovine brain		71012-19-6	Price

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