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Treating Transgenic Alzheimer Mice With a β-secretase Inhibitor, What Have We Learned?

Jordan Tang, Arun Ghosh

Aging (Albany NY). 2011 Jan;3(1):14-6.

PMID: 21248377

Abstract:

β-Secretase is an attractive target of amyloid-reduction therapy for Alzheimer's disease. Currently, no efficacy data is available from clinical trials of β-secretase inhibitors. Treating young transgenic Tg2576 mice with a brain-penetrating β-secretase inhibitor reduced brain amyloid-β by about 50% and rescued the age-related cognitive decline. Implications from these model studies on the design of clinical trials are discussed herein.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4245018 β-Secretase inhibitor β-Secretase inhibitor Price
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