Home
Resources
Publications
Treatment of Adenoviral Keratoconjunctivitis With a Combination of Povidone-Iodine 1.0% and Dexamethasone 0.1% Drops: A Clinical Prospective Controlled Randomized Study

Treatment of Adenoviral Keratoconjunctivitis With a Combination of Povidone-Iodine 1.0% and Dexamethasone 0.1% Drops: A Clinical Prospective Controlled Randomized Study

Natalya Kovalyuk, Igor Kaiserman, Michael Mimouni, Ornit Cohen, Shmuel Levartovsky, Hilda Sherbany, Michal Mandelboim

Acta Ophthalmol. 2017 Dec;95(8):e686-e692.

PMID: 28342227

Abstract:

Purpose:
To determine the efficacy of combination povidone-iodine (PVP-I) 1.0% eyedrops and dexamethasone 0.1% eyedrops in the treatment of adenoviral keratoconjunctivitis.
Materials and methods:
In a prospective, randomized, controlled, double-blinded clinical trial patients with recent adenoviral keratoconjunctivitis (diagnosed clinically and confirmed by PCR), we randomly divided into three treatment groups: study group - received PVP-I 1.0% and dexamethasone 0.1%, control 1 group - received dexamethasone 0.1% and control 2 group - received lubricating eyedrops (hypromellose 0.3%). The treatment was administered four times a day in each group. All patients were examined and filled a questionnaire before treatment and on the 3rd, 5th and 7th days of treatment.
Results:
We included in the study 78 eyes (26 in each group). Adenovirus type 8 was the most common pathogen (83% of cases). The fastest improvement in patients red eyes, discharge, superficial punctate keratitis and pseudomembranes was observed in the study group (p < 0.001). Those patients reached a near complete recovery in 5-7 days, which was also confirmed by reduction in Adenovirus titres by PCR. The slowest improvement was in the control 2 group. Subepithelial infiltrates (SEI) were observed in 44% of the control 1 group, 20% of the control 2 group and in 0% of the study group. The rate of reduction in Adenovirus titres was the slowest in the control 1 group.
Conclusion:
The combination of PVP-I 1.0% and dexamethasone 0.1% four times a day can reduce symptoms and expedite recovery in epidemic keratoconjunctivitis patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004653-A	Hypromellose		9004-65-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: