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Treatment of Bladder Pain Syndrome and Interstitial Cystitis: A Systematic Review

Treatment of Bladder Pain Syndrome and Interstitial Cystitis: A Systematic Review

Carolina Pazin, Andréia Moreira de Souza Mitidieri, Ana Paula Moreira Silva, Maria Beatriz Ferreira Gurian, Omero Benedicto Poli-Neto, Julio Cesar Rosa-E-Silva

Int Urogynecol J. 2016 May;27(5):697-708.

PMID: 26272202

Abstract:

Introduction and hypothesis:
Bladder pain syndrome/interstitial cystitis (BPS/IC) has various treatments; however, no standardized treatment has been established. The aim was to analyze different types of treatment of BPS/IC and their effectiveness.
Methods:
A literature review with a search strategy for articles related to BPS/IC published between 1990 and 2014 was conducted on MEDLINE, PUBMED, and SCOPUS. Only randomized controlled trials in women were included in the meta-analysis, while other experimental studies were used as bases for a systematic review of the topic. Clinical trial quality was defined according to the Jadad scale.
Results:
Of 356 articles, 13 were included in the analysis. The intervention methods were as follows: instillation of hyaluronic acid, botulinum toxin A, intravesical lidocaine, hyperbaric chamber, massage, physiotherapy, phosphate-buffered saline, piroxicam in combination with doxepin, and others. We did not find any treatment with at least two randomized controlled trials for meta-analysis. Among the assessment tools for symptoms of BPS/IC, the most frequently used were the visual analogue scale, voiding record, and the O'Leary-Sant questionnaire.
Conclusion:
Existing studies were not able to define the best approach for the treatment of BPS/IC. The lack of standardized treatment may be related to the diversity of interventions used; therefore, further studies with better methodological quality are needed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS23101	Chloride Standard for IC			Price

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