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Treatment of Urokinase-Related Anaphylactoid Reaction With Intravenous Famotidine

Treatment of Urokinase-Related Anaphylactoid Reaction With Intravenous Famotidine

R R Vidovich, D E Heiselman, D Hudock

Ann Pharmacother. 1992 Jun;26(6):782-3.

PMID: 1611161

Abstract:

Objective:
We describe our experience with an anaphylactoid reaction to urokinase and the treatment used. We also discuss the use of histamine H1- and H2-blockers in combination for the treatment of allergic anaphylactoid reactions.
Design:
Case report.
Setting:
Hospital.
Participants:
Observation of a patient who had a pulmonary embolism.
Intervention:
During the use of urokinase, in treatment of a pulmonary embolism, the patient developed an anaphylactoid reaction that did not respond to diphenhydramine or hydrocortisone. Famotidine was administered.
Results:
Abatement of urticaria and normalization of vital signs were obtained soon after famotidine was given. Completion of thrombolysis took place.
Conclusions:
Further investigation of the use of H1- and H2-blocking agents in the presence of anaphylactoid reactions to thrombolytic agents should be performed. Consideration of intravenous famotidine for the treatment of anaphylactoid-type reactions to urokinase is suggested.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107880740	Famotidine Related Compound F		107880-74-0	Price

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