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Triboelectrification of Active Pharmaceutical Ingredients: Week Acids and Their Salts

Kenta Fujinuma, Yuji Ishii, Yasuo Yashihashi, Estuo Yonemochi, Kiyohiko Sugano, Katsuhide Tarada

Int J Pharm. 2015 Sep 30;493(1-2):434-8.

PMID: 26253375

Abstract:

The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic acids showed negative chargeability, whereas their sodium salts showed more positive chargeability than the free acids. However, no such trend was observed for amide-enole type acids.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP14663231 Dantrolene sodium salt Dantrolene sodium salt 14663-23-1 Price
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