0

Trifluoroacetic Anhydride Promoted Tandem Conjugate Addition of Boronic acids/acetal Ring Opening

Silvia Roscales, Aurelio G Csáky

Org Lett. 2012 Mar 2;14(5):1187-9.

PMID: 22339156

Abstract:

A new stereoselective tandem reaction consisting of the metal-free conjugate addition of boronic acids followed by an intramolecular ring opening of a cyclic acetal has been disclosed. Optically pure polysubstituted tetrahydropyrans have been synthesized diastereoselectively by this new reaction. Two new C-C bonds and up to three stereocenters are formed in a single step, allowing the generation of quaternary stereocenters.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS793889 (4-chlorocarbonylphenyl)boronic anhydride (4-chlorocarbonylphenyl)boronic anhydride Price
qrcode