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Trillin, a Steroidal Saponin Isolated From the Rhizomes of Dioscorea Nipponica, Exerts Protective Effects Against Hyperlipidemia and Oxidative Stress

Trillin, a Steroidal Saponin Isolated From the Rhizomes of Dioscorea Nipponica, Exerts Protective Effects Against Hyperlipidemia and Oxidative Stress

Tiejie Wang, Roy C Y Choi, Jun Li, Cathy W C Bi, Wei Ran, Xiaohui Chen, Tina T X Dong, Kaishun Bi, Karl W K Tsim

J Ethnopharmacol. 2012 Jan 6;139(1):214-20.

PMID: 22100563

Abstract:

Ethnopharmacological evidence:
Numerous efforts have been conducted in searching for effective agents against cardiovascular diseases, in particular from herbal medicines. The rhizome of Dioscorea nipponica (Dioscoreae Nipponicae Rhizoma) is a traditional Chinese herb being prescribed to improve the blood circulation. Here, we identified a steroidal saponin trillin from Dioscorea nipponica, which showed robust anti-hyperlipidemic effects.
Materials and methods:
Rats were induced for hyperlipidemia and subjected to the drug treatment. The anti-hyperlipidemic effects of trillin were evaluated by different biochemical assays.
Results:
In hyperlipidemic rat model, fed with high-fat diet, the blood levels of cholesterol, triglyceride, low density lipoprotein (LDL) and high density lipoprotein (HDL) were increased. The intra-peritoneal administration of trillin into those rats significantly improved the bleeding and blood coagulation time, and in parallel the treatment restored the levels of cholesterol, glyceride, LDL and HDL back to the normal condition. In addition, the administration of trillin in rats exerted beneficial effects in improving the levels of lipid peroxidation and superoxide dismutase activity.
Conclusion:
This was the first time to reveal the anti-hyperlipidemic and anti-oxidative effects of trillin. These results would be important in developing food supplements for health improvements and therapeutic drugs against hyperlipidemia and cardiovascular diseases in future.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14144060	Trillin		14144-06-0	Price

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