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Triparanol Suppresses Human Tumor Growth in Vitro and in Vivo

Triparanol Suppresses Human Tumor Growth in Vitro and in Vivo

Xinyu Bi, Xingpeng Han, Fang Zhang, Miao He, Yi Zhang, Xiu-Yi Zhi, Hong Zhao

Biochem Biophys Res Commun. 2012 Aug 31;425(3):613-8.

PMID: 22877755

Abstract:

Despite the improved contemporary multidisciplinary regimens treating cancer, majority of cancer patients still suffer from adverse effects and relapse, therefore posing a significant challenge to uncover more efficacious molecular therapeutics targeting signaling pathways central to tumorigenesis. Here, our study have demonstrated that Triparanol, a cholesterol synthesis inhibitor, can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol. Remarkably, we have proved Triparanol can significantly repress Hedgehog pathway signaling in these human cancer cells. Furthermore, study in a mouse xenograft model of human lung cancer has validated that Triparanol can impede tumor growth in vivo. We have therefore uncovered Triparanol as potential new cancer therapeutic in treating multiple types of human cancers with deregulated Hedgehog signaling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78411	Triparanol		78-41-1	Price

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