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TRPC3 Is a Major Contributor to Functional Heterogeneity of Cerebellar Purkinje Cells

TRPC3 Is a Major Contributor to Functional Heterogeneity of Cerebellar Purkinje Cells

Bin Wu, François Gc Blot, Aaron Benson Wong, Catarina Osório, Youri Adolfs, R Jeroen Pasterkamp, Jana Hartmann, Esther Be Becker, Henk-Jan Boele, Chris I De Zeeuw, Martijn Schonewille

Elife. 2019 Sep 5;8:e45590.

PMID: 31486767

Abstract:

Despite the canonical homogeneous character of its organization, the cerebellum plays differential computational roles in distinct sensorimotor behaviors. Previously, we showed that Purkinje cell (PC) activity differs between zebrin-negative (Z-) and zebrin-positive (Z+) modules (Zhou et al., 2014). Here, using gain-of-function and loss-of-function mouse models, we show that transient receptor potential cation channel C3 (TRPC3) controls the simple spike activity of Z-, but not Z+ PCs. In addition, TRPC3 regulates complex spike rate and their interaction with simple spikes, exclusively in Z- PCs. At the behavioral level, TRPC3 loss-of-function mice show impaired eyeblink conditioning, which is related to Z- modules, whereas compensatory eye movement adaptation, linked to Z+ modules, is intact. Together, our results indicate that TRPC3 is a major contributor to the cellular heterogeneity that introduces distinct physiological properties in PCs, conjuring functional heterogeneity in cerebellar sensorimotor integration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1262333254	(Z)-N′-Methylmeloxicam		1262333-25-4	Price

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