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Trypanocidal and Leishmanicidal Activities of Flavonoids From Argentine Medicinal Plants

Trypanocidal and Leishmanicidal Activities of Flavonoids From Argentine Medicinal Plants

Valeria P Sülsen, Silvia I Cazorla, Fernanda M Frank, Flavia C Redko, Claudia A Anesini, Jorge D Coussio, Emilio L Malchiodi, Virginia S Martino, Liliana V Muschietti

Am J Trop Med Hyg. 2007 Oct;77(4):654-9.

PMID: 17978066

Abstract:

In vitro trypanocidal and leishmanicidal activities of the flavonoids hispidulin, from Ambrosia tenuifolia, and santin, from Eupatorium buniifolium, are reported. A sensitive technique that takes advantage of ((3)H)thymidine uptake by dividing trypanosomatids has been adjusted for quantification of the parasiticidal effect of the natural products. The IC(50) values for hispidulin and santin on Trypanosoma cruzi epimastigotes were 46.7 and 47.4 muM, respectively. On trypomastigotes, the IC(50) values were 62.3 microM for hispidulin and 42.1 microM for santin. Hispidulin was more active than santin on promastigotes of Leishmania mexicana (IC(50) = 6.0 microM versus 32.5 microM). No cytotoxic activity was observed on lymphoid cells, making hispidulin and santin potential lead compounds for the development of new natural drugs. This is the first report on the trypanocidal and leishmanicidal activities of these flavonoids and on the presence of santin in E. buniifolium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27782634	Santin		27782-63-4	Price

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