0

Tsavoenones A-C: Unprecedented Polyketides With a 1,7-dioxadispiro[4.0.4.4]tetradecane Core From the Lichen Parmotrema Tsavoense

Thuc-Huy Duong, Mehdi A Beniddir, Grégory Genta-Jouve, Thammarat Aree, Marylène Chollet-Krugler, Joël Boustie, Solenn Ferron, Aurélie Sauvager, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Warinthorn Chavasiri, etc.

Org Biomol Chem. 2018 Aug 15;16(32):5913-5919.

PMID: 30074046

Abstract:

New racemic dispiranic polyketides, tsavoenones A (1), B (2) and C (3), having a novel 1,7-dioxadispiro[4.0.4.4]tetradecane scaffold were isolated from the foliose lichen Parmotrema tsavoense. These compounds were structurally elucidated by extensive NMR analyses, comparison between experimental and theoretical 13C NMR data and X-ray crystallography. A putative biosynthetic scenario for the formation of 1-3 from parmosidone D, a meta-depsidone previously isolated from the same lichen material, was proposed. Tested for its cytotoxicity, 1 displayed a moderate activity against human myelogenous leukemia K562 cell line with an IC50 value of 66 μg mL-1.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP629594 Tetradecane Tetradecane 629-59-4 Price
qrcode