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Tungsten (VI) Based "Molecular Puzzle" Photoluminescent Nanoparticles Easily Covered With Biocompatible Natural Polysaccharides via Direct Chelation

Tungsten (VI) Based "Molecular Puzzle" Photoluminescent Nanoparticles Easily Covered With Biocompatible Natural Polysaccharides via Direct Chelation

Volodymyr Lobaz, Martin Hladik, Miloš Steinhart, Aleksandra Paruzel, Peter Černoch, Jiří Pánek, Miroslav Vetrík, Daniel Jirák, Markéta Jirátová, Ognen Pop-Georgievski, Miroslav Šlouf, Sébastien Garcia-Argote, etc.

J Colloid Interface Sci. 2018 Feb 15;512:308-317.

PMID: 29078182

Abstract:

Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu3+ or Tb3+ nanoparticles (size range of 10-160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling. For WO3, the sorption is reversible. However, on CaWO4, stable coating is formed. CaWO4/Tb3+ coated with chemisorbed dextrin, mannan, guar gum and sodium alginate successfully underwent endocytosis with HepG2 cells and was visualized using confocal microscopy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1314358	Tungsten(VI) oxide		1314-35-8	Price

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