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Two Are Better Than One: Dual Targeting of Riboswitches by Metabolite Analogs

Stefanie Sandra Krajewski, Dmitry Ignatov, Jörgen Johansson

Cell Chem Biol. 2017 May 18;24(5):535-537.

PMID: 28525764

Abstract:

In this issue of Cell Chemical Biology, Wang et al. (2017) examine the effect of the novel synthetic molecule ribocil-C and the natural compound roseoflavin in Gram-positive pathogens. In methicillin-resistant Staphylococcus aureus (MRSA), ribocil-C and roseoflavin target two autonomous riboswitches simultaneously, thereby inhibiting de novo synthesis and uptake of riboflavin.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1825355563 Ribocil-C Ribocil-C 1825355-56-3 Price
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