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Two New Resorcinol Derivatives With Strong Cytotoxicity From the Roots of Ardisia Brevicaulis Diels

Two New Resorcinol Derivatives With Strong Cytotoxicity From the Roots of Ardisia Brevicaulis Diels

Li Bao, Manyuan Wang, Feng Zhao, Yisong Zhao, Hongwei Liu

Chem Biodivers. 2010 Dec;7(12):2901-7.

PMID: 21162003

Abstract:

Two new resorcinol derivatives, 4-hydroxy-2-methoxy-6-[(8Z)-pentadec-8-en-1-yl]phenyl acetate (1) and 4-hydroxy-2-methoxy-6-pentadecylphenyl acetate (2), together with known compounds ardisiphenol D (3), 5-tridecylresorcinol (4), 5-pentadecylresorcinol (5), 5-[(8Z)-pentadec-8-en-1-yl]resorcinol (6), belamcandaquinones C and D (7 and 8, resp.), ardisicrenoside A, ardisiacrispin B, (22E)-24-ethyl-5α-cholesta-7,22-dien-3-one, and (22E)-24-ethyl-5α-cholesta-7,22-dien-3β-ol were isolated from the MeOH extract of the roots of Ardisia brevicaulis Diels. Their structures were determined by spectroscopic analysis including ESI- and EI-MS, and NMR data. Cytotoxicities of 1-4 against cell lines A549, MCF-7, and PANC-1 were tested in vitro by the MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method. Compounds 1-4 showed cytotoxic activity against all cell lines stronger than that of cisplatin against A549.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3158563	5-Pentadecylresorcinol		3158-56-3	Price

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