Home
Resources
Publications
Two Types of Calcium Channels Sensitive to Omega-Agatoxin- TK in Cultured Rat Hippocampal Neurones

Two Types of Calcium Channels Sensitive to Omega-Agatoxin- TK in Cultured Rat Hippocampal Neurones

T Teramoto, T Niidome, T Miyagawa, Y Nishizawa, K Katayama, K Sawada

Neuroreport. 1995 Aug 21;6(12):1684-8.

PMID: 8527741

Abstract:

We characterized the electrophysiological properties of calcium channels in cultured rat hippocampal neurones using omega-agatoxin-TK (omega-Aga-TK) and compared them with those of the P-type channel and the BI (alpha 1A) channel which resembles the Q-type channel. Two types of omega-Aga-TK-sensitive calcium channels were detected in hippocampal neurones. The first type showed slow inactivation, high sensitivity to omega-Aga-TK and low reversibility from omega-Aga-TK-induced block, resembling the P-type channel. The second type showed fast inactivation, low sensitivity to omega-Aga-TK and high reversibility from omega-Aga-TK-induced block. These results suggest that the second type of calcium channel (Q-type-like) plays a prominent role in the hippocampal synaptic transmission.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP158484425	ω-Agatoxin TK		158484-42-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: