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Type IV Hypersensitivity to Vitamin K

Type IV Hypersensitivity to Vitamin K

Sabine Sommer, S Mark Wilkinson, Daniel Peckham, Caroline Wilson

Contact Dermatitis. 2002 Feb;46(2):94-6.

PMID: 11918602

Abstract:

The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP573206	Vitamin K4		573-20-6	Price

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