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Tyrphostin-induced Inhibition of p210bcr-abl Tyrosine Kinase Activity Induces K562 to Differentiate

M Anafi, A Gazit, A Zehavi, Y Ben-Neriah, A Levitzki

Blood. 1993 Dec 15;82(12):3524-9.

PMID: 7505115

Abstract:

We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid differentiation. AG 568 and especially AG 1112 represent a specific group of nontoxic protein tyrosine kinase blockers among more than 1,400 tested. These compounds possess therapeutic potential for purging Philadelphia chromosome-positive cells in preparation for autologous bone marrow transplantation in chronic myelogenous leukemia.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP153150846 Tyrphostin AG 1112 Tyrphostin AG 1112 153150-84-6 Price
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