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UCN3 Suppresses Food Intake in Coordination With CCK and the CCK2R in Siberian Sturgeon (Acipenser Baerii)

UCN3 Suppresses Food Intake in Coordination With CCK and the CCK2R in Siberian Sturgeon (Acipenser Baerii)

Ni Tang, Xin Zhang, Shuyao Wang, Jinwen Qi, Zhengzhi Tian, Bin Wang, Hu Chen, Yuanbing Wu, Mei Wang, Shaoqi Xu, Defang Chen, Zhiqiong Li

Comp Biochem Physiol A Mol Integr Physiol. 2019 Aug;234:106-113.

PMID: 31051262

Abstract:

Urocortin-3 (UCN3) as a brain-gut peptide inhibits food intake of animal, but the underlying mechanism is not clear. To explore the appetite mechanism about the action of UCN3 in fish, intraperitoneal injection of UCN3 with CCK8, Lorglumide (CCK1R antagonist) or LY225910 (CCK2R antagonist) were conducted. Siberian sturgeon administrated with UCN3 and CCK8 showed a drastic reduction in food intake. The anorectic effect of UCN3 was significantly blocked by LY225910, but not affected by Lorglumide. Furthermore, LY225910 could effectively reverse appetite factor mRNA expressions, including cck, pyy, cart, npy, ucn3, apelin and nucb2 in the whole brain, stomach and intestinum valvula, but Lorglumide could only partially reverse these effects, suggesting the anorectic effect of UCN3 may be primarily mediated CCK2R in Siberian sturgeon. This study indicates for the first time in fish that UCN3 may inhibit food intake in coordination with CCK and CCK2R.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP133040774	LY225910		133040-77-4	Price

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