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Ultrasound-assisted Synthesis of Highly Functionalized benzo[1,3]thiazine via Cu-catalyzed Intramolecular CH Activation Reaction From Isocyanides, Aniline-Benzoyl(acetyl) Isothiocyanate Adduct

Manijeh Nematpour, Elham Rezaee, Mehdi Jahani, Sayyed Abbas Tabatabai

Ultrason Sonochem. 2019 Jan;50:1-5.

PMID: 30213458

Abstract:

A facile sonochemical route for the synthesis of benzo[1,3]thiazine derivatives via a one pot, multicomponent, intramolecular CH activation reaction from isocyanides, aniline and benzoyl (acetyl) isothiocyanate adduct catalyzed by copper (I) iodide in acetone at 30 °C have been reported. The advantages of the described method include using simple and readily available starting materials and performing under mild copper-catalytic reaction conditions and also obtaining pure product with high yield without applying column chromatography. Furthermore, using the sonochemical methodology as an efficient method led to reduce the reaction times.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13250469 Acetyl isothiocyanate Acetyl isothiocyanate 13250-46-9 Price
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