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Ultrasound Responsive Block Copolymer Micelle of Poly(ethylene Glycol)-Poly(propylene Glycol) Obtained Through Click Reaction

Ultrasound Responsive Block Copolymer Micelle of Poly(ethylene Glycol)-Poly(propylene Glycol) Obtained Through Click Reaction

Fayong Li, Chuan Xie, Zhengang Cheng, Hesheng Xia

Ultrason Sonochem. 2016 May;30:9-17.

PMID: 26703197

Abstract:

The well-defined amphiphilic poly(ethylene glycol)-block-poly(propylene glycol) copolymer containing 1, 2, 3-triazole moiety and multiple ester bonds (PEG-click-PPG) was prepared by click reaction strategy. The PEG-click-PPG copolymer can self-assemble into spherical micelles in aqueous solution. It is found that high intensity focused ultrasound (HIFU) can open the copolymer PEG-click-PPG micelles and trigger the release of the payload in the micelle. The multiple ester bonds introduced in the junction point of the copolymer chain through click reactions were cleaved under HIFU, and leads to the disruption of the copolymer micelle and fast release of loaded cargo. The click reaction provides a convenient way to construct ultrasound responsive copolymer micelles with weak bonds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25322694	Poly(propylene glycol)		25322-69-4	Price

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