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Understanding the Role of 3-O-Acetyl-11-keto-β-boswellic Acid in Conditions of Oxidative-Stress Mediated Hepatic Dysfunction During Benzo(a)pyrene Induced Toxicity

Understanding the Role of 3-O-Acetyl-11-keto-β-boswellic Acid in Conditions of Oxidative-Stress Mediated Hepatic Dysfunction During Benzo(a)pyrene Induced Toxicity

Manoj Kumar, Gurpreet Singh, Priti Bhardwaj, Sunil Kumar Dhatwalia, D K Dhawan

Food Chem Toxicol. 2017 Nov;109(Pt 2):871-878.

PMID: 28363852

Abstract:

The present study was planned to see whether 3-O-Acetyl-11- keto-β-boswellic acid has any protective effects against benzo(a)pyrene (BaP) induced toxicity or not. In vitro studies show concentration dependent linear association of radical scavenging activity of AK which is comparable to ascorbic acid taken as reference compound. For in vivo studies, the animals were divided randomly into five groups which included a) normal control, b) vehicle treated (olive oil), c) BaP treated, d) AK treated and e) AK + BaP (combined treated). BaP was administered at a dose of 50mg/kg in olive oil twice a week orally for 4 weeks and AK (50mg/kg) was given in olive oil thrice a week for 4 weeks before and after BaP exposure. BaP treated animals showed a significant increase (p < 0.001) in lipid peroxidation (LPO) and protein carbonyl contents (PCC) in hepatic tissue. Further, a significant increase (p < 0.001) in the liver marker enzymes as well as citrulline and nitric oxide levels in the hepatic tissue was also observed. Interestingly, AK when supplemented to BaP treated animals ameliorated the above said biochemical indices appreciately. The histopathological observations also showed appreciable improvement when BaP treated animals were supplemented with AK, thus emphasing the protective potential of AK.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67416619	3-O-Acetyl-11-keto-β-boswellic acid		67416-61-9	Price

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