Unexpected Listeria Monocytogenes Detection With a Dithiothreitol-Based Device During an Aseptic Hip Revision

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Unexpected Listeria Monocytogenes Detection With a Dithiothreitol-Based Device During an Aseptic Hip Revision

Unexpected Listeria Monocytogenes Detection With a Dithiothreitol-Based Device During an Aseptic Hip Revision

Giuliana Banche, Alessandro Bistolfi, Valeria Allizond, Claudia Galletta, Maria Rita Iannantuoni, Elisa Simona Marra, Chiara Merlino, Alessandro Massè, Anna Maria Cuffini

Future Microbiol. 2018 Sep;13:1295-1299.

PMID: 29909646

Abstract:

Prosthetic joint infection diagnosis is often difficult since biofilm-embedded microorganisms attach well to the prosthetic surfaces and resist their detection by conventional methods. DL-dithiothreitol has been described as a valid method for biofilm detachment on orthopedic devices. We report the case of an occasional detection of Listeria monocytogenes in a non immuno-compromised patient with a preoperative diagnosis of aseptic loosening. The infection diagnosis due to such rare bacteria was made postoperatively, thanks to a DL-dithiothreitol-based device. This may be considered a feasible approach for the microbiological analysis of prosthetic joint infection, considering that a prompt diagnosis of such biofilm-associated infections could bring some advantages, such as an early and appropriate antibiotic therapy administration and a reduction of undiagnosed infections.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3483123	DL-Dithiothreitol		3483-12-3	Price

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