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Unusual Findings of Acute Myeloid Leukemia With inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A Multicenter Study

Unusual Findings of Acute Myeloid Leukemia With inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A Multicenter Study

Xubo Gong, Teng Yu, Qiusu Tang, Yanbiao Fu, Jie Wu, Yongze Zhu, Hongxiang Tu, Haifeng Ge, Xingguo Lu, Donghua Gong, Xiaoying Zhao

Int J Lab Hematol. 2019 Jun;41(3):380-386.

PMID: 30793839

Abstract:

Introduction:
AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) [inv(3)/t(3;3)] was very rare. Currently, most reports of AML-inv(3)/t(3;3) were from Western countries, and few reports were from Asian countries. Racial differences in patients with AML-inv(3)/t(3;3) are still unknown.
Methods:
Between January 1996 and April 2018, a total of 37 AML cases with inv(3)/t(3;3) were studied retrospectively. They were collected from 2229 primary AML cases performed with conventional cytogenetic analysis (37/2229, 1.66%).
Results:
Here, some differences were found by comparing our data with those from Western countries. In our series, AML with inv(3)(q21q26) had a lower incidence than that with t(3;3)(q21;q26) (11 vs 26 cases). Our patients seemed to be more younger (median, 43 years) and have lower hemoglobin concentrations (median, 73 g/L) and higher platelet count (median, 351 × 109 /L). A higher incidence of acute monoblastic and monocytic leukemia (45.9%) was observed in our patients. Immunophenotypic studies showed that CD38 (30.8%) was not so frequently expressed as that in the earlier reports. Mutations analysis showed a high frequency of NRAS mutations (45.0%), followed by SF3B1(15.0%), GATA2(15.0%), FLT3-ITD(10.0%), C-Kit/D816(5.0%), and CEBPA(5.0%), without mutation of NPM1(Exon12)or JAK2V617.
Conclusion:
Ethnic differences do exist between the Chinese and Western patients with AML-inv(3)/t(3;3), and more attention should be paid involving different ethnic populations and geographic regions.

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