0

Urine Xanthine Crystals in Tumor Lysis Syndrome

Ayumi Omokawa, Mariko Oguma, Shigeharu Ueki, Tomoo Saga, Makoto Hirokawa

Urology. 2018 Oct;120:e9-e10.

PMID: 30030092

Abstract:

Urine xanthine crystals are remarkably rare but can be observed by routine urine microscopy. We report the results of a 67-year-old man with T-cell-prolymphocytic leukemia whose urine contained xanthine crystals after chemotherapy and prophylactic administration of febuxostat. Accumulation of xanthine was due to tumor lysis syndrome causing a massive release of DNA. The metabolized DNA caused an increase of xanthine, which was not readily converted to uric acid by xanthine oxidase because of febuxostat inhibition of this enzyme.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP69896 Xanthine Xanthine 69-89-6 Price
qrcode