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Ursolic Acid Modulates MMPs, collagen-I, α-SMA, and TGF-β Expression in Isoproterenol-Induced Myocardial Infarction in Rats

Ursolic Acid Modulates MMPs, collagen-I, α-SMA, and TGF-β Expression in Isoproterenol-Induced Myocardial Infarction in Rats

T Radhiga, S Senthil, A Sundaresan, K V Pugalendi

Hum Exp Toxicol. 2019 Jul;38(7):785-793.

PMID: 30977399

Abstract:

In the present study, the modulatory effect of ursolic acid (UA) on cardiac fibrosis and mitochondrial and lysosomal enzymes activity in isoproterenol-induced myocardial infarction (MI) in rats were examined. Isoproterenol hydrochloride (ISO; 85 mg/kg body weight) was administered subcutaneously for first two consecutive days. ISO-induced MI in rats significantly decreased the activities of mitochondrial tricarboxylic acid cycle enzymes and respiratory chain enzymes while increased the activities of lysosomal glycohydrolases and cathepsins. The expression of matrix metalloproteinase 2 (MMP-2), MMP-9, collagen type I, α-smooth muscle actin (α-SMA), and transforming growth factor-β (TGF-β) were upregulated in ISO-induced MI in rats. UA administration to rats showed increased activities of mitochondrial tricarboxylic acid cycle enzymes and respiratory chain enzymes and decreased activities of lysosomal glycohydrolases and cathepsins in ISO-induced rats. Furthermore, expression of MMP-2, MMP-9, collagen type I, α-SMA, and TGF-β downregulated in UA-administered rats. Thus, our results demonstrate that UA has an anti-fibrotic effect and attenuates the mitochondrial and lysosomal dysfunction in ISO-induced MI in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51309-A	Isoproterenol hydrochloride		51-30-9	Price
AP5984952	(−)-Isoproterenol hydrochloride		5984-95-2	Price

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