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Use of Derivatized Cyclodextrins as Chiral Selectors for the Separation of Enantiomers by Gas Chromatography

Use of Derivatized Cyclodextrins as Chiral Selectors for the Separation of Enantiomers by Gas Chromatography

V Schurig

Ann Pharm Fr. 2010 Mar;68(2):82-98.

PMID: 20434597

Abstract:

The state-of-the-art of enantioseparations of various chiral compounds on derivatized cyclodextrins, employed as chiral stationary phases (CSPs) by gas chromatography, is reviewed. Heptakis(2,3,6-O-trimethyl)-beta-cyclodextrin and octakis(3-O-butanoyl-2,6-di-O-pentyl)-gamma-cyclodextrin (Lipodex E), either dissolved in a semipolar polysiloxane or bonded to poly(dimethylsiloxane) (Chirasil-Dex), proved to be the most popular chiral selectors. Special applications refer to the use of heptakis (2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-beta-cyclodextrin and heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-beta-cyclodextrin. Enantioselectivity is generally low with enantioseparation factors in the range of 1.02

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7413147	Octakis (2,6-di-O-pentyl)-γ-cyclodextrin			Price

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