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Use of Inactivated Escherichia Coli Enterotoxins to Enhance Respiratory Mucosal Adjuvanticity During Vaccination in Swine

Roger W Barrette, Steven M Szczepanek, Debra Rood, Sreerupa Challa, Naomi Avery, Michael Vajdy, Ed Kramer, Luis Rodriguez, Lawrence K Silbart

Clin Vaccine Immunol. 2011 Nov;18(11):1996-8.

PMID: 21918121

Abstract:

In order to augment responses to respiratory vaccines in swine, various adjuvants were intranasally coadministered with a foot-and-mouth disease virus (FMDV) antigen to pigs. Detoxified Escherichia coli enterotoxins LTK63 and LTR72 enhanced antigen-specific mucosal and systemic immunity, demonstrating their efficacy as adjuvants for nonreplicating antigens upon intranasal immunization in swine.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42410690 Inactivated Escherichia coli Inactivated Escherichia coli Price
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