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Use of Lipids to Potentiate the Antibacterial Activity of Aminoglycosides

Use of Lipids to Potentiate the Antibacterial Activity of Aminoglycosides

J R Gilbertson, H H Langkamp, R Connamacher, D Platt

Antimicrob Agents Chemother. 1984 Sep;26(3):306-9.

PMID: 6508262

Abstract:

Linolenyl alcohol has been shown to inhibit the in vitro growth of several species of gram-positive bacteria. Since the double bonds in linolenyl alcohol could undergo autooxidation, the antimicrobial activities of saturated primary alcohols of similar molecular sizes against Streptococcus mutans BHT were evaluated. Tridecan-1-ol was identified as the most active compound, eliciting a bacteriostatic effect at concentrations at which growth occurred in the presence of other saturated alcohols or linolenyl alcohol. Evidence is also presented that the combined use of tridecan-1-ol and gentamicin sulfate produces a synergistic effect that is bactericidal to S. mutans BHT. A similar bactericidal response was observed when tridecan-1-ol was combined with other aminoglycosides or tested alone against other strains of S. mutans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP506445	Linolenyl alcohol		506-44-5	Price

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