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Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives

Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives

Heba Kamal Abd El-Mawgoud, Saad Ramadan Atta-Allah, Magdy Mohamed Hemdan

Chem Pharm Bull (Tokyo). 2018;66(10):992-998.

PMID: 30270245

Abstract:

The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP148961880	2-Tributylstannylbenzo[b]thiophene		148961-88-0	Price
AP420089516	Thiophene-2		420089-51-6	Price

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