Home
Resources
Publications
Utility of Indigo Carmine Angiography in Patients With Critical Limb Ischemia: Prospective Multi-Center Intervention Study (DIESEL-study)

Utility of Indigo Carmine Angiography in Patients With Critical Limb Ischemia: Prospective Multi-Center Intervention Study (DIESEL-study)

Akihiro Higashimori, Mitsuyoshi Takahara, Makoto Utsunomiya, Masashi Fukunaga, Daizo Kawasaki, Shinsuke Mori, Hideyuki Takimura, Keisuke Hirano, Yoshinori Tsubakimoto, Tatsuya Nakama, Yoshiaki Yokoi

Catheter Cardiovasc Interv. 2019 Jan 1;93(1):108-112.

PMID: 30144339

Abstract:

Objectives:
To assess the efficacy of indigo carmine angiography for wound healing after successful below-the-knee intervention in patients with critical limb ischemia (CLI).
Methods:
A multi-center prospective intervention study was conducted. Fifty-four limbs of 53 patients in Rutherford categories 5 and 6 underwent endovascular therapy (EVT). After successful EVT, 5 mL of indigo carmine was injected through a catheter at the distal popliteal artery and color changes in the foot were evaluated. The results of indigo carmine angiography were divided into three groups: In type I, the color change of the wound was deeper than the surrounding tissue; in type II, the change in wound color was similar to the surrounding tissue; and in type III, no discoloration of the wound was observed by the indigo carmine.
Results:
The wound healing rates at 3 months were 78% (25/32) for type I, 70% (7/10) for type II, and 42% (5/12) for type III (P for trend = 0.025). Indigo carmine angiography-related complications were not seen.
Conclusion:
Indigo carmine angiography was found to be a safe and useful procedure to provide visual information on foot perfusion. This dye coloring method demonstrated that after successful angioplasty, the perfused area was made visible at the microcirculation level. Indigo carmine angiography can thus be considered an important predictor for wound healing by EVT in patients with CLI.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP860220-A	Indigo carmine		860-22-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: