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Utilization of N-acetyl-L-tyrosine and glycyl-L-tyrosine During Long-Term Parenteral Nutrition in the Growing Rat

Utilization of N-acetyl-L-tyrosine and glycyl-L-tyrosine During Long-Term Parenteral Nutrition in the Growing Rat

M Neuhäuser, J A Wandira, U Göttmann, K H Bässler, K Langer

Am J Clin Nutr. 1985 Oct;42(4):585-96.

PMID: 3931451

Abstract:

Utilization of N-acetyl-L-tyrosine and glycyl-L-tyrosine as a source of tyrosine in infusion solutions was tested in rats receiving total parenteral nutrition for 4 wk. The four solutions tested were isonitrogenous and isocaloric. One of the solutions contained an adequate amount of L-phenylalanine; in the other three, two-thirds of the phenylalanine was replaced by a corresponding amount of either glycine, glycyl-L-tyrosine or N-acetyl-L-tyrosine. No differences in weight gain or N-balance could be detected as a result of administering either the solution with glycyl-L-tyrosine or with N-acetyl-L-tyrosine in place of the solution containing an adequate phenylalanine content. The solution in which two-thirds of the L-phenylalanine was replaced by glycine yielded only half of the weight gain and correspondingly reduced values for N-balance. Daily urinary excretion rates for N-acetyl-L-tyrosine and glycyl-L-tyrosine were 11% and 0.5%, respectively, of the infused amount. Plasma amino acid pattern was affected differently by the four solutions. The results indicate that both N-acetyl-L-tyrosine and glycyl-L-tyrosine are efficiently utilized by the rat during total parenteral nutrition.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39630461	Glycyl-L-tyrosine		39630-46-1	Price

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