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Validation of a Multi-Residue Liquid Chromatography-Tandem Mass Spectrometry Confirmatory Method for 10 Anticoccidials in Eggs According to Commission Decision 2002/657/EC

Validation of a Multi-Residue Liquid Chromatography-Tandem Mass Spectrometry Confirmatory Method for 10 Anticoccidials in Eggs According to Commission Decision 2002/657/EC

Estelle Dubreil-Chéneau, Mélaine Bessiral, Brigitte Roudaut, Eric Verdon, Pascal Sanders

J Chromatogr A. 2009 Nov 13;1216(46):8149-57.

PMID: 19442981

Abstract:

A liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the simultaneous detection and confirmation of halofuginone, robenidine, diclazuril, nicarbazin, monensin, narasin, lasalocid, salinomycin, maduramicin and semduramicin in whole egg has been developed and validated. The anticoccidial residues were extracted by acetonitrile, evaporated and dissolved in a sodium acetate/acetonitrile mixture. Then, the samples were injected on a C8 column in a gradient mode. Diclazuril-bis, DNC-d8 and nigericin were used as internal standards. The results of the full validation in accordance with the guidelines of the Commission Decision no 2002/657/EC are presented. This rapid and sensitive method was found suitable to confirm the anticoccidials at 1 and at 75 microg kg(-1) for the MRL compound lasalocid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1156508870	DNC-d8		1156508-87-0	Price

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