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Variability of Delivery of Timolol for the Treatment of Infantile Hemangiomas

Variability of Delivery of Timolol for the Treatment of Infantile Hemangiomas

JiaDe Yu, Tucker Keuter, Kala Schilter, Marcia Seefeldt, Brittney Bates, Katherine Mueller, Beth A Drolet

Pediatr Dermatol. 2017 Jul;34(4):458-460.

PMID: 28660677

Abstract:

Background/objectives:
Topical timolol maleate solution or gel-forming solution is used alone or in conjunction with oral propranolol for the treatment of infantile hemangiomas. The consistency of the amount of timolol dispensed has never been evaluated. We evaluated the variability of drug delivery between different brands and formulations of timolol solution and gel-forming solution.
Methods:
Five blinded volunteers sequentially dispensed five drops from each of the eight bottles containing timolol 0.5% solution or gel-forming solution. This was repeated three times per user for each bottle. The average amount of timolol dispensed was analyzed according to brand, formulation, and user for variability. The intra- and interuser variability of dispensing both formulations of timolol was also measured.
Results:
Our study demonstrates statistically significant differences in the amount of timolol dispensed between timolol solution and gel-forming solution, with the latter closer to manufacturer estimates. Significant differences in the amount of timolol dispensed were noted between users regardless of the formulation or brand. Variability in the amount of timolol dispensed was greater for gel-forming solution than 0.5% solution. Inter- and intrauser variability in the amount of timolol dispensed was greater for gel-forming solution than 0.5% solution.
Conclusion:
Statistically significant differences were noted in the amount of timolol dispensed according to formulation, brand, and user. Whether this is clinically significant is unknown given the lack of pharmacokinetic data available for timolol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1219806457	Chlorpheniramine-D6 maleate solution		1219806-45-7	Price
AP136765474	(±)-Norpropoxyphene-d5 maleate solution		136765-47-4	Price

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