Home
Resources
Publications
Vasodilator Responses to Alpha-Human-Atrial Natriuretic Peptide in Isolated Omental and Pulmonary Arteries From Rabbit and Man

Vasodilator Responses to Alpha-Human-Atrial Natriuretic Peptide in Isolated Omental and Pulmonary Arteries From Rabbit and Man

F Lindberg, K E Andersson

Acta Physiol Scand. 1988 Nov;134(3):391-7.

PMID: 2976241

Abstract:

In isolated vessels from the pulmonary and mesenteric/omental arterial circulations of rabbit and man, the effects of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) were investigated. The vessels had an outer diameter of 0.6-1.2 mm and were contracted by noradrenaline (NA) and prostaglandin (PG) F2 alpha (mesenteric/omental arteries) or by 5-hydroxytryptamine (5-HT) and PGF2 alpha (pulmonary arteries). It was found that in rabbits, mesenteric vessels contracted by NA and PGF2 alpha were not significantly relaxed by alpha-hANP. Rabbit pulmonary vessels contracted by PGF2 alpha or 5-HT were concentration-dependently relaxed by alpha-hANP (maximum 70%). Human omental vessels contracted by NA and PGF2 alpha showed a moderate (30%) relaxation after addition of the peptide. Human pulmonary arteries contracted by 5-HT were relaxed by alpha-hANP almost to baseline, while PGF2 alpha-contracted vessels showed a maximum relaxation of 65%. It is concluded that alpha-hANP has a relatively selective effect on pulmonary arterial vessels from rabbit as well as man. The results suggest that the peptide may be involved in the regulation of pulmonary vascular tone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP91917634	Atrial Natriuretic Peptide human		91917-63-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: