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VEGF-A and PlGF-1 Stimulate Chemotactic Migration of Human Mesenchymal Progenitor Cells

VEGF-A and PlGF-1 Stimulate Chemotactic Migration of Human Mesenchymal Progenitor Cells

Jörg Fiedler, Frank Leucht, Johannes Waltenberger, Christoph Dehio, Rolf E Brenner

Biochem Biophys Res Commun. 2005 Aug 26;334(2):561-8.

PMID: 16005848

Abstract:

Vascular endothelial growth factor (VEGF) has been indicated to play a role during endochondral ossification by stimulation of blood vessel invasion into hypertrophic cartilage resulting in its replacement by trabecular bone. We could demonstrate a dose-dependent chemoattractive effect of VEGF-A and PlGF-1, but not VEGF-E or VEGF-C, on human mesenchymal progenitor cells. Quantitative realtime PCR revealed the expression of VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4), which markedly declined during osteogenic differentiation. In addition, expression of neuropilin-1 and -2 was detected by RT-PCR. In an in vitro kinase assay, we could demonstrate activation of VEGFR-1 and VEGFR-2 upon stimulation with specific ligands. These findings are consistent with the idea that the chemotactic effect of VEGF-A on MPC is mediated via VEGFR-1, and that VEGF-A and PlGF-1, have a functional role for recruitment of osteoprogenitor cells in the course of endochondral bone formation or remodeling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413778	PLGF-1 human			Price

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