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Verbenone Structural Analogues Isolated From Artemesia Aucheri as Natural Acaricides Against Dermatophagoides Spp. And Tyrophagus Putrescentiae

Verbenone Structural Analogues Isolated From Artemesia Aucheri as Natural Acaricides Against Dermatophagoides Spp. And Tyrophagus Putrescentiae

Ji-Yeon Yang, Hoi-Seon Lee

J Agric Food Chem. 2013 Dec 18;61(50):12292-6.

PMID: 24295367

Abstract:

The acaricidal activities of Artemisia aucheri oil and (1S)-(-)-verbenone structural analogues were evaluated using a fumigant method against Dermatophagoides farinae , Dermatophagoides pteronyssinus , and Tyrophagus putrescentiae and then compared to those of benzyl benzoate. On the basis of the LD50 values against D. farinae , (1S)-(-)-verbenone (1.38 μg/cm(2)) was about 7.4 times more active than benzyl benzoate (10.15 μg/cm(2)), followed by (+)-trans-myrtanol (2.27 μg/cm(2)), (-)-trans-myrtanol (2.30 μg/cm(2)), and A. aucheri oil (8.75 μg/cm(2)). (1S)-(-)-Verbenone (1.25 μg/cm(2)) was approximately 7.8 times more effective against D. pteronyssinus than benzyl benzoate (9.80 μg/cm(2)), followed by (+)-trans-myrtanol (2.18 μg/cm(2)), (-)-trans-myrtanol (2.22 μg/cm(2)), and A. aucheri oil (8.46 μg/cm(2)). In the case of T. putrescentiae , (1S)-(-)-verbenone (3.75 μg/cm(2)) was roughly 3.5 times more toxic than benzyl benzoate (13.25 μg/cm(2)), followed by (+)-trans-myrtanol (12.57 μg/cm(2)), (-)-trans-myrtanol (12.95 μg/cm(2)), and A. aucheri oil (11.55 μg/cm(2)). These results indicate that A. aucheri oil and (1S)-(-)-verbenone structural analogues may be effective natural agents to control house dust and storage mites.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1196016	(1S)-(−)-Verbenone		1196-01-6	Price

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