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Viral Complementation of Immunodeficiency Confers Protection Against Enteric Pathogens via interferon-λ

Viral Complementation of Immunodeficiency Confers Protection Against Enteric Pathogens via interferon-λ

Harshad Ingle, Sanghyun Lee, Teresa Ai, Anthony Orvedahl, Rachel Rodgers, Guoyan Zhao, Meagan Sullender, Stefan T Peterson, Marissa Locke, Ta-Chiang Liu, Christine C Yokoyama, Bridgett Sharp, Stacey Schultz-Cherry, etc.

Nat Microbiol. 2019 Jul;4(7):1120-1128.

PMID: 30936486

Abstract:

Commensal microbes profoundly impact host immunity to enteric viral infections1. We have shown that the bacterial microbiota and host antiviral cytokine interferon-λ (IFN-λ) determine the persistence of murine norovirus in the gut2,3. However, the effects of the virome in modulating enteric infections remain unexplored. Here, we report that murine astrovirus can complement primary immunodeficiency to protect against murine norovirus and rotavirus infections. Protection against infection was horizontally transferable between immunocompromised mouse strains by co-housing and fecal transplantation. Furthermore, protection against enteric pathogens corresponded with the presence of a specific strain of murine astrovirus in the gut, and this complementation of immunodeficiency required IFN-λ signalling in gut epithelial cells. Our study demonstrates that elements of the virome can protect against enteric pathogens in an immunodeficient host.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413322	IFN-lambda 2 from mouse			Price

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