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Visualizing Mitochondrial F o F 1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423

Visualizing Mitochondrial F o F 1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423

Ilka Starke, Gary D Glick, Michael Börsch

Front Physiol. 2018 Jul 4;9:803.

PMID: 30022951

Abstract:

Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and induces apoptosis via increased reactive oxygen production in coupled, actively respiring mitochondria. Here, we review the experimental progress to reveal the binding of Bz-423 to the mitochondrial target and discuss how subunit rotation of FoF1-ATP synthase is affected by Bz-423. Briefly, we report how Förster resonance energy transfer can be employed to colocalize the enzyme and the fluorescently tagged Bz-423 within the mitochondria of living cells with nanometer resolution.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP216691951	Bz-423		216691-95-1	Price

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