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Vitamin D Treatment Abrogates the Inflammatory Response in Paraquat-Induced Lung Fibrosis

Vitamin D Treatment Abrogates the Inflammatory Response in Paraquat-Induced Lung Fibrosis

Adriana Schapochnik, Marcia Rodrigues da Silva, Mayara Peres Leal, Janete Esteves, Cristina Bichels Hebeda, Silvana Sandri, Daniela de Fátima Teixeira da Silva, Sandra Helena Poliseli Farsky, Rodrigo Labat Marcos, etc.

Toxicol Appl Pharmacol. 2018 Sep 15;355:60-67.

PMID: 29944852

Abstract:

A high incidence of intentional or accidental paraquat (PQ) ingestion is related to irreversible lung fibrosis and no effective therapy is currently available. Vitamin D has emerged with promising results as an immunomodulatory molecule when abrogating the inflammatory responses of lung diseases. Therefore, we have investigated the role of vitamin D treatments on PQ-induced lung fibrosis in male C57/BL6 mice. Lung fibrosis was induced by a single injection of PQ (10 mg/kg; i.p.). The control group received PQ vehicle. Seven days later, after the PQ injection or the vehicle injection, the mice received vitamin D (5 μg/kg, i.p., once a day) or vehicle, for a further 7 days. Twenty-four hours after the last dose of vitamin D or the vehicle, the analysis were performed. The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues. Conversely, the vitamin D treatments increased the resolvin D levels in their BALF. Moreover, their tracheal contractility was also significantly reduced by the vitamin D treatments. Altogether, the data that was obtained showed a promising use of vitamin D, in treating the lung fibrosis that had been induced by the PQ intoxications. This may improve its prognostic use for a non-invasive and low cost therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP927691212	PQ-10		927691-21-2	Price

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