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Voltage-dependent Removal of Sodium Inactivation by N-bromoacetamide and Pronase

Voltage-dependent Removal of Sodium Inactivation by N-bromoacetamide and Pronase

V L Salgado, J Z Yeh, T Narahashi

Biophys J. 1985 Apr;47(4):567-71.

PMID: 2580570

Abstract:

When perfused internally through crayfish giant axons, pronase removed sodium inactivation more than three times as fast at -100 mV as compared with -30 mV. N-bromoacetamide, applied internally, removed sodium inactivation twice as fast at -100 mV as at -30 mV, and the relative rate of removal declined with membrane depolarization in proportion to steady-state sodium inactivation. We conclude that in the closed conformation the sodium inactivation gate is partially protected from destruction by N-bromoacetamide and pronase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP79152	N-Bromoacetamide		79-15-2	Price

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