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Voltammetric Determination of 5-hydroxytryptamine Based on the Use of Platinum Nanoparticles Coated With Molecularly Imprinted Silica

Voltammetric Determination of 5-hydroxytryptamine Based on the Use of Platinum Nanoparticles Coated With Molecularly Imprinted Silica

Yiwen Yang, Yanbo Zeng, Chuangui Tang, Xudong Zhu, Xing Lu, Lingyu Liu, Zhidong Chen, Lei Li

Mikrochim Acta. 2018 Mar 13;185(4):219.

PMID: 29594696

Abstract:

The authors describe an electrochemical sensor for the determination of 5-hydroxytryptamine (5-HT; serotonin). It is based on the use of platinum nanoparticles (PtNPs) coated with molecularly imprinted silica (MIS). The MIS-coated PtNPs were prepared from 5-HT, PtNPs, phenyltrimethoxysilane and tetraethoxysilane that act as template, support, functional monomer and cross-linker, respectively. The MIS-coated PtNPs were characterized by Fourier transfer infrared spectroscopy and transmission electron microscopy. The MIS-coated PtNPs were drop-cast onto a glassy carbon electrode (GCE) to obtain an electrochemical sensor for 5-HT which exhibited fast response and high recognition ability for 5-HT. The imprinting factor of this electrode for 5-HT is 4.12, which is higher than that for its analogs. Under optimized conditions and at a typical working potential of 0.29 V (vs. Hg/Hg2Cl2), the electrode has a linear response in the 0.05-80 μM 5-HT concentration range and a 0.02 μM detection limit. The electrode was successfully applied to the determination of 5-HT in human serum samples. Graphical Abstract Molecularly imprinted silica-coated platinum nanoparticles were prepared using surface imprinting technique. A glassy carbon electrode modified with the surface imprinted material exhibits fast response in detecting 5-hydroxytryptamine, a low detection limit, good selectivity, reproducibility and stability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS72329	Platinum on silica			Price

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