Home
Resources
Publications
Water-compatible Silica Sol-Gel Molecularly Imprinted Polymer as a Potential Delivery System for the Controlled Release of Salicylic Acid

Water-compatible Silica Sol-Gel Molecularly Imprinted Polymer as a Potential Delivery System for the Controlled Release of Salicylic Acid

Bin Li, Jingjing Xu, Andrew J Hall, Karsten Haupt, Bernadette Tse Sum Bui

J Mol Recognit. 2014 Sep;27(9):559-65.

PMID: 25042710

Abstract:

Molecularly imprinted polymers (MIPs) for salicylic acid were synthesized and evaluated in aqueous environments in the aim to apply them as drug delivery carriers. One organic MIP and one inorganic MIP based on the sol-gel process were synthesized. The organic MIP was prepared by radical polymerization using the stoichiometric functional monomer, 1-(4-vinylphenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea, which can establish strong electrostatic interactions with the -COOH of salicylic acid. The sol-gel MIP was prepared with 3-(aminopropyl)triethoxysilane and trimethoxyphenylsilane, as functional monomers and tetraethyl orthosilicate as the crosslinker. While the organic MIPs bound the target specifically in acetonitrile, they exhibited lower binding in the presence of water, although the imprinting factor increased under these conditions, due to reduced non-specific binding. The sol-gel MIP has a high specificity and capacity for the drug in ethanol, a solvent compatible with drug formulation and biomedical applications. In vitro release profiles of the polymers in water were evaluated, and the results were modelled by Fick's law of diffusion and the power law. Analysis shows that the release mechanism was predominantly diffusion-controlled.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2996921	Trimethoxyphenylsilane		2996-92-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: