Home
Resources
Publications
Water-soluble Inclusion Complex of Fullerene With γ-cyclodextrin Polymer for Photodynamic Therapy

Water-soluble Inclusion Complex of Fullerene With γ-cyclodextrin Polymer for Photodynamic Therapy

Wang Zhang, Xiangdong Gong, Chang Liu, Yuanzhe Piao, Yun Sun, Guowang Diao

J Mater Chem B. 2014 Aug 21;2(31):5107-5115.

PMID: 32261845

Abstract:

A stable aqueous inclusion complex of fullerene (C60) with macromolecules (C60 concentration as high as 3 × 10-4 mol L-1) was achieved by a one-step strategy using γ-cyclodextrin polymer (γ-CDP). The inclusion complex of C60 with γ-CDP (C60-γ-CDP) was characterized by ultraviolet-visible, Raman and 1H-NMR spectroscopies, powder X-ray diffraction analysis, and thermogravimetric analysis. The supramolecular interactions and the equilibrium constant for a 1 : 2 (C60 : CD unit in γ-CDP) complex of C60 with γ-CDP were studied. Under ultraviolet A (UVA) irradiation C60-γ-CDP in water could generate singlet oxygen, which was detected by electron paramagnetic resonance spectroscopy. We also evaluated the cytotoxicities of C60-γ-CDP, and investigated the phototoxicity of C60-γ-CDP and pristine C60 toward B16-F10 melanoma cells. The cell viability test showed that C60-γ-CDP had a significantly higher photodynamic ability than that of the pristine C60 under UVA irradiation. This work demonstrated both a CDP-functionalized strategy for enhancing the water-solubility and phototoxicity of fullerenes for applications in cancer photodynamic therapy, as well as remediating the negative biological effects of pristine fullerenes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741353	γ-Cyclodextrin polymer, soluble			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: