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Wheat Germ Lipase Catalyzed Kinetic Resolution of Secondary Alcohols in Non-Aqueous Media

Xiaole Xia, Yong-Hua Wang, Bo Yang, Xiaoning Wang

Biotechnol Lett. 2009 Jan;31(1):83-7.

PMID: 18777014

Abstract:

The lipase from wheat germ was used for the kinetic resolution of secondary alcohols. It has the opposite enantioselectivity against the Kazlauskas rule and acts as an anti-Kazlauskas catalyst. The effect of initial water activity, organic solvent, acyl donor and temperature were investigated. Wheat germ lipase had a high activity and enantioselectivity only in n-hexane with a high initial water activity (alpha(w) = 0.97), especially with 1-phenylethanol (C 32%, E > 200). Its performance changed little with the chain length of acyl donor and temperature.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9001621-I Lipase from wheat germ Lipase from wheat germ 9001-62-1 Price
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