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Wild Parsnip (Pastinaca Sativa)-Induced Photosensitization

Wild Parsnip (Pastinaca Sativa)-Induced Photosensitization

Bryan L Stegelmeier, Steven M Colegate, Edward L Knoppel, Kerry A Rood, Mark G Collett

Toxicon. 2019 Sep;167:60-66.

PMID: 31173794

Abstract:

Wild parsnip (Pastinaca sativa) has been associated with livestock and human photosensitization. An investigation of a natural occurrence of photosensitization of grazing horses identified wild parsnip as a possible cause. HPLC-MS and MS/MS analysis of this plant identified five furanocoumarins i.e., xanthotoxin, bergapten, isopimpinellin, imperatorin and a putative methoxyimperatorin. Goats fed this wild parsnip were largely unaffected. Xanthotoxin was not detected in the serum of parsnip-fed goats or in the serum of goats dosed orally or intravenous with purified xanthotoxin. Cutaneous application produced severe photodermatitis in goats and a horse consistent with topical exposure as the likely route to produce wild parsnip-induced photosensitivity. Wild parsnip-induced superficial necrotizing dermatitis was consistent with photodermatitis with no evidence of other allergic or inflammatory components.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP482279	Isopimpinellin		482-27-9	Price

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