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WISP-3 Inhibition of miR-452 Promotes VEGF-A Expression in Chondrosarcoma Cells and Induces Endothelial Progenitor Cells Angiogenesis

WISP-3 Inhibition of miR-452 Promotes VEGF-A Expression in Chondrosarcoma Cells and Induces Endothelial Progenitor Cells Angiogenesis

Chih-Yang Lin, Huey-En Tzeng, Te-Mao Li, Hsien-Te Chen, Yi Lee, Yi-Chen Yang, Shih-Wei Wang, Wei-Hung Yang, Chih-Hsin Tang

Oncotarget. 2017 Jun 13;8(24):39571-39581.

PMID: 28465477

Abstract:

Chondrosarcoma is the second most prevalent general primary tumor of bone following osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). VEGF-A level has been recognized as a prognostic marker in angiogenesis. WNT1-inducible signaling pathway protein-3 (WISP)-3/CCN6 belongs to the CCN family and is involved in regulating several cellular functions, including cell proliferation, differentiation, and migration. Nevertheless, the effect of WISP-3 on VEGF-A production and angiogenesis in human chondrosarcoma remains largely unknown. This current study shows that WISP-3 promoted VEGF-A production and induced angiogenesis of human endothelial progenitor cells. Moreover, WISP-3-enhanced VEGF-A expression and angiogenesis involved the c-Src and p38 signaling pathways, while miR-452 expression was negatively affected by WISP-3 via the c-Src and p38 pathways. Our results illustrate the clinical significance of WISP-3, VEGF-A and miR-452 in human chondrosarcoma patients. WISP-3 may illustrate a novel therapeutic target in the metastasis and angiogenesis of chondrosarcoma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413773	WISP-3 human			Price

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