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Withanolide Z, a New Chlorinated Withanolide From Withania Somnifera

Swapan Pramanick, Amit Roy, Shekher Ghosh, Hemanta K Majumder, Sibabrata Mukhopadhyay

Planta Med. 2008 Nov;74(14):1745-8.

PMID: 18988152

Abstract:

Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The Leishmania donovani DNA topoisomerase I inhibitory activities of the isolated compounds were determined.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP56973412 Withanolide B Withanolide B 56973-41-2 Price
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