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Withanone-rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis Through hnRNP-K

Withanone-rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis Through hnRNP-K

Ran Gao, Navjot Shah, Jung-Sun Lee, Shashank P Katiyar, Ling Li, Eonju Oh, Durai Sundar, Chae-Ok Yun, Renu Wadhwa, Sunil C Kaul

Mol Cancer Ther. 2014 Dec;13(12):2930-40.

PMID: 25236891

Abstract:

Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27570383	Withanone		27570-38-3	Price

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