Home
Resources
Publications
Withanoside IV Improves Hindlimb Function by Facilitating Axonal Growth and Increase in Peripheral Nervous System Myelin Level After Spinal Cord Injury

Withanoside IV Improves Hindlimb Function by Facilitating Axonal Growth and Increase in Peripheral Nervous System Myelin Level After Spinal Cord Injury

Natsuki Nakayama, Chihiro Tohda

Neurosci Res. 2007 Jun;58(2):176-82.

PMID: 17386954

Abstract:

Although methylprednisolone is the clinically standard medication and almost the only therapy for spinal cord injury (SCI), its effect on functional recovery remains questionable. Transplantation strategies using sources such as neural stem cells and embryonic spinal cord still have some hurdles to overcome before practical applications become available. We therefore aimed to develop a practical medication for SCI. Per oral treatment with withanoside IV, which was previously shown to regenerate neuronal networks in the brain, improved locomotor functions in mice with SCI. In the spinal cord after SCI, axons were crushed in the white matter and gray matter, and central nervous system (CNS) myelin level decreased. In mice treated with withanoside IV (10micromol/kg body weight/day, for 21 days), axonal density and peripheral nervous system (PNS) myelin level increased. The loss of CNS myelin and increase in reactive gliosis were not affected by withanoside IV. These results suggest that oral administration of withanoside IV may ameliorate locomotor functions by facilitating both axonal regrowth and increase in PNS myelin level.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP362472819	Withanoside IV		362472-81-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: